Compare the Top On-Premises Antivirus Software as of October 2026

What is On-Premises Antivirus Software?

Antivirus software helps protect computers, networks, and mobile devices from malicious threats such as viruses, malware, ransomware, spyware, and trojans. These platforms typically scan files and programs for known threats, block suspicious activity, and remove harmful software from systems. Antivirus software often includes real-time protection, automatic updates, and scheduled scans to ensure ongoing security. Additionally, many antivirus programs offer web protection, email scanning, and firewall features to prevent cyber-attacks and data breaches. By using antivirus software, individuals and businesses can safeguard their devices, maintain privacy, and ensure the integrity of their data. Compare and read user reviews of the best On-Premises Antivirus software currently available using the table below. This list is updated regularly.

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    ManageEngine Endpoint Central
    ManageEngine Endpoint Central includes next-generation antivirus (NGAV) and anti-ransomware protection that goes beyond traditional signature-based detection using behavioral analysis and AI-driven intelligence to identify and block known, unknown, and zero-day threats before they execute on managed endpoints. Unlike conventional antivirus solutions that rely solely on known virus definitions, Endpoint Central's NGAV continuously monitors endpoint behavior to detect suspicious activity, fileless malware, and advanced attack techniques that evade traditional security tools. Ransomware-specific protection identifies encryption-like behavior in real time, isolating and neutralizing threats before they can spread across the network. Automated threat remediation restores affected files and system components, while built-in rollback capabilities reverse unauthorized changes ensuring endpoints can be restored to a clean, trusted state with minimal disruption to business operations.
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    Starting Price: $1.09/endpoint/month
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  • 2
    ESET PROTECT Advanced
    ESET Protect Advanced is a comprehensive cybersecurity solution designed for businesses of all sizes. It offers advanced endpoint protection against ransomware, zero-day threats, and sophisticated attacks with ESET LiveSense technology. It includes full disk encryption for legal compliance and data protection. The solution features proactive cloud-based threat defense using adaptive scanning, machine learning, cloud sandboxing, and behavioral analysis to prevent new threats. Mobile threat defense secures Android and iOS devices with anti-malware, anti-theft, and mobile device management. It also provides cloud app protection, mail server security, and vulnerability and patch management. Extended detection and response (XDR) enhances threat detection and response, while multi-factor authentication adds security. The solution offers single-pane-of-glass remote management for visibility into threats and users, along with advanced reporting and custom notifications.
    Starting Price: $275/month/5 devices
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  • 3
    N-able N‑central
    Join the thousands of MSPs and IT professionals who use N-able™ N-central® to remotely monitor and manage devices and complex networks. Key features include: • Monitor almost any device, including support for Windows, Linux, and macOS • Gain complete insight across your network and cloud services without the need for extra network monitoring software • Create automated patch management policies to ensure devices are up to date • Streamline your workflow with drag-and-drop scripting in automation manager—no need to write a line of code • Provide remote support across devices and platforms with the integrated Take Control feature • Integrate your existing PSA software or use N-able MSP Manager to manage tickets and billing • Manage security with integrated backup, EDR, AV, and disk encryption • Available as an on-premises or hosted cloud solution to fit your business
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